Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Quintero ML
PROVIDER: S-EPMC7426445 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Fernández-Quintero Monica L ML Loeffler Johannes R JR Bacher Lisa M LM Waibl Franz F Seidler Clarissa A CA Liedl Klaus R KR
Frontiers in molecular biosciences 20200807
During the affinity maturation process the immune system produces antibodies with higher specificity and activity through various rounds of somatic hypermutations in response to an antigen. Elucidating the affinity maturation process is fundamental in understanding immunity and in the development of biotherapeutics. Therefore, we analyzed 10 pairs of antibody fragments differing in their specificity and in distinct stages of affinity maturation using metadynamics in combination with molecular dy ...[more]