Ontology highlight
ABSTRACT:
SUBMITTER: Ming J
PROVIDER: S-EPMC7426519 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ming Jie J Cronin Shane J F SJF Penninger Josef M JM
Frontiers in oncology 20200807
RANKL and RANK are expressed in different cell types and tissues throughout the body. They were originally described for their essential roles in bone remodeling and the immune system but have subsequently been shown to provide essential signals from regulating mammary gland homeostasis during pregnancy to modulating tumorigenesis. The success of RANKL/RANK research serves as a paragon for translational research from the laboratory to the bedside. The case in point has been the development of De ...[more]