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Melanoma brain metastases: review of histopathological features and immune-molecular aspects.

ABSTRACT: Patients with melanoma brain metastases (MBM) have a dismal prognosis, but the unprecedented advances in systemic therapy alone or in combination with local therapy have now extended the 1-year overall survival rate from 20-25% to nearing 80-85%, mainly in asymptomatic patients. The histopathological and molecular characterization of MBM and the understanding of the microenvironment are critical to more effectively manage patients with advanced melanoma and to design biologically driven clinical trials. This review aims to give an overview of the main histopathological features and the immune-molecular aspects of MBM.

SUBMITTER: Salvati L

PROVIDER: S-EPMC7426753 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Melanoma brain metastases: review of histopathological features and immune-molecular aspects.

Salvati Lorenzo L Mandalà Mario M Massi Daniela D

Melanoma management 20200608 2

Patients with melanoma brain metastases (MBM) have a dismal prognosis, but the unprecedented advances in systemic therapy alone or in combination with local therapy have now extended the 1-year overall survival rate from 20-25% to nearing 80-85%, mainly in asymptomatic patients. The histopathological and molecular characterization of MBM and the understanding of the microenvironment are critical to more effectively manage patients with advanced melanoma and to design biologically driven clinical ...[more]

PMID: 32821376

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Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.

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