Dataset Information

Evaluation of biochemical and hematological parameters in adults with Down syndrome.

ABSTRACT: Down syndrome (DS) is the most common worldwide cause of intellectual disability of genetic origin and the most common chromosomal disorder affecting live-born infants. In addition to intellectual disability, individuals with DS have other comorbidities and complex medical conditions. The increase in the life expectancy of patients with DS requires expanding the knowledge about their clinical characteristics and related laboratory parameters. Several studies exploring laboratory tests in DS patients exist, but their focus is limited to specific areas of metabolism. Therefore, our main goal was to describe the biochemical and hematological findings in a DS cohort and to compare the values to those of a control population. A total of 248 DS individuals and 84 control subjects were enrolled. DS individuals had a higher frequency of several clinical conditions compared to control individuals and presented with significant differences with respect to the controls in both biochemical and hematological parameters. We found age- and sex-related differences in several of the parameters. A good understanding of the differences in our cohort might be of aid in the clinical follow-up of adults with DS, especially considering that the lifespan of DS individuals may reach 60 years of age in developed countries.

SUBMITTER: de Gonzalo-Calvo D

PROVIDER: S-EPMC7426851 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Evaluation of biochemical and hematological parameters in adults with Down syndrome.

de Gonzalo-Calvo David D Barroeta Isabel I Nan Madalina Nicoleta MN Rives José J Garzón Diana D Carmona-Iragui María M Benejam Bessy B Videla Laura L Fernández Susana S Altuna Miren M Valldeneu Sílvia S Blesa Rafael R Lleó Alberto A Blanco-Vaca Francisco F Fortea Juan J Tondo Mireia M

Scientific reports 20200813 1

Down syndrome (DS) is the most common worldwide cause of intellectual disability of genetic origin and the most common chromosomal disorder affecting live-born infants. In addition to intellectual disability, individuals with DS have other comorbidities and complex medical conditions. The increase in the life expectancy of patients with DS requires expanding the knowledge about their clinical characteristics and related laboratory parameters. Several studies exploring laboratory tests in DS pati ...[more]

PMID: 32792619

Similar Datasets

Project description:Background:CDC's (Centers for Disease Control and Prevention) National Center for Health statistics recent reports have shown that an upsurge has occurred in the use of dietary supplements among age of 20 years since 1994 and this use shown regular increase. The purpose of our study was to investigate the effect of supplements on the reproductive health on male athletes in Pakistan. Methods:A total of 150 adult male with mean age of 25.78?±?0.56 years were included in this study and divided into four groups: Non-athlete control (n?=?57), Non supplemental athlete control (n?=?40), Supplemental athlete group I (n?=?28) and supplemental athlete group II (n?=?25). Blood (10 ml) was taken from each subject. Complete blood count was performed and 5 ml of blood was centrifuged to separate plasma and then analyzed for antioxidant enzyme (CAT, POD, GR and GSH) activities, Lipid peroxidation (TBARS), electrolyte, metal (sodium, potassium and zinc) and Luteinizing hormone (LH) concentration. Results:Complete blood count results showed normal RBC, WBC, Platelets, Hemoglobin, Hematocrit, Mean corpuscular hemoglobin and Mean corpuscular hemoglobin concentration. Antioxidant enzymes (CAT, POD, GR, GSH) increased significantly in supplemental athletes as compared to control groups. Sodium and potassium showed significant increase (p?<?0.001) in supplemental athlete group I, while TBARS also showed significant increase (p?<?0.05) in supplemental group I and II as compared to non athlete control while non supplemental athletes showed significant increase (p?<?0.05) in TBARS concentration as compared to non athlete control. LH concentration was found to be decreased significantly (p?<?0.05) in supplemental group I and II as compared to control groups. Conclusion:It is therefore concluded from the present results that oxidative stress was considerably elevated in response to supplement consumption among athletes which may affect their health haematological parameters and reproductive hormones.

Dataset Information

Evaluation of biochemical and hematological parameters in adults with Down syndrome.

Publications

Evaluation of biochemical and hematological parameters in adults with Down syndrome.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets