Y chromosome in health and diseases.
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ABSTRACT:
SUBMITTER: Lau YC
PROVIDER: S-EPMC7427063 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Sex differences are prevalent in normal development, physiology and disease pathogeneses. Recent studies have demonstrated that mosaic loss of Y chromosome and aberrant activation of its genes could modify the disease processes in male biased manners. This mini review discusses the nature of the genes on the human Y chromosome and identifies two general categories of genes: those sharing dosage-sensitivity functions with their X homologues and those with testis-specific expression and functions. ...[more]
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