Metabolic syndrome in haemodialysis patients: prevalence, determinants and association to cardiovascular outcomes.

ABSTRACT: BACKGROUND:In the general population, metabolic syndrome (MetS) is predictive of major adverse cardiovascular events (MACE). Waist circumference (WC), a component of the MetS criteria, is linked to visceral obesity, which in turn is associated with MACE. However, in haemodialysis (HD) patients, the association between MetS, WC and MACE is unclear. METHODS:In a cross-sectional study of 1000 HD patients, we evaluated the prevalence and characterised the clinical predictors of MetS. The relationship between MetS and its components, alone or in combination, and MACE (coronary diseases, peripheral arteriopathy, stroke or cardiac failure), was studied using receiver operating characteristics (ROC) curves and logistic regression. RESULTS:A total of 753 patients were included between October 2011 and April 2013. The prevalence of MetS was 68.5%. Waist circumference (>?88?cm in women, 102?cm in men) was the best predictor of MetS (sensitivity 80.2; specificity 82.3; AUC 0.80; p?

SUBMITTER: Delautre A 

PROVIDER: S-EPMC7427285 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature