Ontology highlight
ABSTRACT:
SUBMITTER: Savardi A
PROVIDER: S-EPMC7427514 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chem 20200806 8
Aberrant expression ratio of Cl<sup>-</sup> transporters, NKCC1 and KCC2, is implicated in several brain conditions. NKCC1 inhibition by the FDA-approved diuretic drug, bumetanide, rescues core symptoms in rodent models and/or clinical trials with patients. However, bumetanide has a strong diuretic effect due to inhibition of the kidney Cl<sup>-</sup> transporter NKCC2, creating critical drug compliance issues and health concerns. Here, we report the discovery of a new chemical class of selectiv ...[more]