Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice.
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ABSTRACT:
SUBMITTER: Ke Z
PROVIDER: S-EPMC7427781 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice.
Ke Zhonghe Z Firsanov Denis D Spencer Brianna B Seluanov Andrei A Gorbunova Vera V
NPJ aging and mechanisms of disease 20200814
Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels ...[more]
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