An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
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ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC7427797 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
Liu Benyu B Ye Buqing B Zhu Xiaoxiao X Yang Liuliu L Li Huimu H Liu Nian N Zhu Pingping P Lu Tiankun T He Luyun L Tian Yong Y Fan Zusen Z
Nature communications 20200814 1
Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that is induced in ILC3s during intestinal inflammation. Deletion of circKcnt2 causes gut ILC3 activation and severe colitis in mice. Mechanistically, circKcnt2, as a nuclear circRNA, recruits the nucleosome remodeling deacetylase (NuRD) complex onto Batf pr ...[more]
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