Dataset Information

Follow the Sex: Influence of Network Structure on the Effectiveness and Cost-Effectiveness of Partner Management Strategies for Sexually Transmitted Infection Control.

ABSTRACT:

Background

It is well established that network structure strongly influences infectious disease dynamics. However, little is known about how the network structure impacts the cost-effectiveness of disease control strategies. We evaluated partner management strategies to address bacterial sexually transmitted infections (STIs) as a case study to explore the influence of the network structure on the optimal disease management strategy.

Methods

We simulated a hypothetical bacterial STI spread through 4 representative network structures: random, community-structured, scale-free, and empirical. We simulated disease outcomes (prevalence, incidence, total infected person-months) and cost-effectiveness of 4 partner management strategies in each network structure: routine STI screening alone (no partner management), partner notification, expedited partner therapy, and contact tracing. We determined the optimal partner management strategy following a cost-effectiveness framework and varied key compliance parameters of partner management in sensitivity analysis.

Results

For the same average number of contacts and disease parameters in our setting, community-structured networks had the lowest incidence, prevalence, and total infected person-months, whereas scale-free networks had the highest without partner management. The highly connected individuals were more likely to be reinfected in scale-free networks than in the other network structures. The cost-effective partner management strategy depended on the network structures, the compliance in partner management, the willingness-to-pay threshold, and the rate of external force of infection.

Conclusions

Our findings suggest that contact network structure matters in determining the optimal disease control strategy in infectious diseases. Information on a population's contact network structure may be valuable for informing optimal investment of limited resources.

SUBMITTER: Kao SZ

PROVIDER: S-EPMC7428058 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Follow the Sex: Influence of Network Structure on the Effectiveness and Cost-Effectiveness of Partner Management Strategies for Sexually Transmitted Infection Control.

Kao Szu-Yu Zoe SZ Enns Eva A EA

Sexually transmitted diseases 20200201 2

<h4>Background</h4>It is well established that network structure strongly influences infectious disease dynamics. However, little is known about how the network structure impacts the cost-effectiveness of disease control strategies. We evaluated partner management strategies to address bacterial sexually transmitted infections (STIs) as a case study to explore the influence of the network structure on the optimal disease management strategy.<h4>Methods</h4>We simulated a hypothetical bacterial S ...[more]

PMID: 31935206

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Project description:ObjectiveTo examine the effectiveness of methods to improve partner notification by patient referral (index patient has responsibility for informing sex partners of their exposure to a sexually transmitted infection).DesignSystematic review of randomised trials of any intervention to supplement simple patient referral.Data sourcesSeven electronic databases searched (January 1990 to December 2005) without language restriction, and reference lists of retrieved articles.Review methodsSelection of trials, data extraction, and quality assessment were done by two independent reviewers. The primary outcome was a reduction of incidence or prevalence of sexually transmitted infections in index patients. If this was not reported data were extracted according to a hierarchy of secondary outcomes: number of partners treated; number of partners tested or testing positive; and number of partners notified, located, or elicited. Random effects meta-analysis was carried out when appropriate.Results14 trials were included with 12 389 women and men diagnosed as having gonorrhoea, chlamydia, non-gonococcal urethritis, trichomoniasis, or a sexually transmitted infection syndrome. All studies had methodological weaknesses that could have biased their results. Three strategies were used. Six trials examined patient delivered partner therapy. Meta-analysis of five of these showed a reduced risk of persistent or recurrent infection in patients with chlamydia or gonorrhoea (summary risk ratio 0.73, 95% confidence interval 0.57 to 0.93). Supplementing patient referral with information for partners was as effective as patient delivered partner therapy. Neither strategy was effective in women with trichomoniasis. Two trials found that providing index patients with chlamydia with sampling kits for their partners increased the number of partners who got treated.ConclusionsInvolving index patients in shared responsibility for the management of sexual partners improves outcomes. Health professionals should consider the following strategies for the management of individual patients: patient delivered partner therapy, home sampling for partners, and providing additional information for partners.

Project description:ImportanceAdolescents and young adults compose almost 50% of all diagnosed sexually transmitted infection (STI) cases annually in the US. Given that these individuals frequently access health care through the emergency department (ED), the ED could be a strategic venue for examining the identification and treatment of STIs.ObjectiveTo examine the cost-effectiveness of screening strategies for Chlamydia trachomatis and Neisseria gonorrhoeae (chlamydia and gonorrhea) in adolescents and young adults who seek acute care at pediatric EDs.Design, setting, and participantsThis economic evaluation is a component of an ongoing, larger multicenter clinical trial at the Pediatric Emergency Care Applied Research Network. A decision analytic model, created using literature-based estimates for the key parameters, was developed to simulate the events and outcomes associated with 3 strategies for screening and testing chlamydial and gonococcal infections in individuals aged 15 to 21 years who sought acute care at pediatric EDs. Data sources included published (from January 1, 1997, to December 31, 2019) English-language articles indexed in MEDLINE, bibliographies in relevant articles, insurance claims data in the MarketScan database, and reimbursement payments from the Centers for Medicare and Medicaid Services. Because the events and outcomes were simulated, a hypothetical population of 10 000 ED visits by adolescents and young adults was used.InterventionsThe 3 screening strategies were (1) no screening, (2) targeted screening, and (3) universally offered screening. Targeted screening involved the completion of a sexual health survey, which yielded an estimated STI risk (at risk, high risk, or low risk).Main outcomes and measuresOutcome metrics included cost (measured in 2019 US dollars) and the detection and successful treatment of STIs. The incremental cost-effectiveness ratio (ICER) of each strategy was calculated in a base case analysis. The ICER reflects the cost per case detected and successfully treated.ResultsA 3.6% prevalence of chlamydia and gonorrhea was applied to a hypothetical population of 10 000 ED visits by adolescents and young adults. Targeted screening resulted in the detection and successful treatment of 95 of 360 STI cases (26.4%) at a cost of $313 063, and universally offered screening identified and treated 112 of 360 STI cases (31.1%) at a cost of $515 503. The ICER for targeted screening vs no screening was $6444, and the ICER for universally offered screening vs targeted screening was $12 139.Conclusions and relevanceThis economic evaluation found that targeted screening and universally offered screening compared with no screening appeared to be cost-effective strategies for identifying and treating chlamydial and gonococcal infections in adolescents and young adults who used the ED for acute care. Universally offered screening was associated with detecting and successfully treating a higher proportion of STIs in this population.

Project description:BackgroundGenital inflammation associated with sexually transmitted infections (STIs) and bacterial vaginosis (BV) is considered a key driver in the HIV epidemic. A new rapid point-of-care test (POC) that detects genital inflammation in women-Genital InFlammation Test (GIFT)-was recently developed by researchers at the University of Cape Town. The objective of this study was to establish the cost-effectiveness of this novel intervention relative to other relevant screening and diagnostic strategies for the management of STIs and BV in women seeking care in the public health sector in South Africa.MethodsA decision analysis model was developed for five different screening and diagnostic strategies for women incorporating syndromic management, screening with GIFT and using etiological diagnosis. A decision tree was constructed using Microsoft Excel Office 365, and cost and effectiveness parameters were obtained from published literature and market prices. The model incorporated all clinic-level and treatment costs associated with diagnosing and treating a single episode of disease. The effectiveness of each approach was proxied by its sensitivity. One-way and threshold sensitivity analyses were conducted to test key uncertainties and assumptions in the model.ResultsScreening with GIFT, and following with antibiotic treatment according to syndromic management guidelines for GIFT-positive cases, was the most cost-effective strategy with an incremental cost-effectiveness ratio (ICER) of USD 11.08 per women diagnosed with an STI(s) and/or BV and provided treatment. This strategy resulted in lower rates of overtreatment compared to syndromic management, but higher rates compared to etiological diagnosis using nucleic acid amplification tests and microscopy. However, following a GIFT positive test with etiological diagnosis prior to treatment did not increase the effectiveness, but dramatically increased the cost.ConclusionScreening with GIFT and treating positive cases according to syndromic management guidelines is the most cost-effective strategy for the management of STIs and BV. GIFT has a potential to significantly improve the management of STIs and BV in women by identifying asymptomatic women and reducing their risk of HIV infection. This analysis presents a first step in establishing the cost-effectiveness of these interventions and paves the way for further research to develop optimal context-specific implementation strategies.

Dataset Information

Follow the Sex: Influence of Network Structure on the Effectiveness and Cost-Effectiveness of Partner Management Strategies for Sexually Transmitted Infection Control.

Background

Methods

Results

Conclusions

Publications

Follow the Sex: Influence of Network Structure on the Effectiveness and Cost-Effectiveness of Partner Management Strategies for Sexually Transmitted Infection Control.

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