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Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy.


ABSTRACT: OBJECTIVES:To describe clinical characteristics, management and outcome of individuals with coronavirus disease 2019 (COVID-19); and to evaluate risk factors for all-cause in-hospital mortality. METHODS:This retrospective study from a University tertiary care hospital in northern Italy, included hospitalized adult patients with a diagnosis of COVID-19 between 25 February 2020 and 25 March 2020. RESULTS:Overall, 317 individuals were enrolled. Their median age was 71 years and 67.2% were male (213/317). The most common underlying diseases were hypertension (149/317; 47.0%), cardiovascular disease (63/317; 19.9%) and diabetes (49/317; 15.5%). Common symptoms at the time of COVID-19 diagnosis included fever (285/317; 89.9%), shortness of breath (167/317; 52.7%) and dry cough (156/317; 49.2%). An 'atypical' presentation including at least one among mental confusion, diarrhoea or nausea and vomiting was observed in 53/317 patients (16.7%). Hypokalaemia occurred in 25.8% (78/302) and 18.5% (56/303) had acute kidney injury. During hospitalization, 111/317 patients (35.0%) received non-invasive respiratory support, 65/317 (20.5%) were admitted to the intensive care unit (ICU) and 60/317 (18.5%) required invasive mechanical ventilation. All-cause in-hospital mortality, assessed in 275 patients, was 43.6% (120/275). On multivariable analysis, age (per-year increase OR 1.07; 95% CI 1.04-1.10; p < 0.001), cardiovascular disease (OR 2.58; 95% CI 1.07-6.25; p 0.03), and C-reactive protein levels (per-point increase OR 1.009; 95% CI 1.004-1.014; p 0.001) were independent risk factors for all-cause in-hospital mortality. CONCLUSIONS:COVID-19 mainly affected elderly patients with predisposing conditions and caused severe illness, frequently requiring non-invasive respiratory support or ICU admission. Despite supportive care, COVID-19 remains associated with a substantial risk of all-cause in-hospital mortality.

SUBMITTER: Vena A 

PROVIDER: S-EPMC7428680 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy.

Vena Antonio A   Giacobbe Daniele Roberto DR   Di Biagio Antonio A   Mikulska Malgorzata M   Taramasso Lucia L   De Maria Andrea A   Ball Lorenzo L   Brunetti Iole I   Loconte Maurizio M   Patroniti Nicolò A NA   Robba Chiara C   Delfino Emanuele E   Dentone Chiara C   Magnasco Laura L   Nicolini Laura L   Toscanini Federica F   Bavastro Martina M   Cerchiaro Matteo M   Barisione Emanuela E   Giacomini Mauro M   Mora Sara S   Baldi Federico F   Balletto Elisa E   Berruti Marco M   Briano Federica F   Sepulcri Chiara C   Dettori Silvia S   Labate Laura L   Mirabella Michele M   Portunato Federica F   Pincino Rachele R   Russo Chiara C   Tutino Stefania S   Pelosi Paolo P   Bassetti Matteo M  

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20200815 11


<h4>Objectives</h4>To describe clinical characteristics, management and outcome of individuals with coronavirus disease 2019 (COVID-19); and to evaluate risk factors for all-cause in-hospital mortality.<h4>Methods</h4>This retrospective study from a University tertiary care hospital in northern Italy, included hospitalized adult patients with a diagnosis of COVID-19 between 25 February 2020 and 25 March 2020.<h4>Results</h4>Overall, 317 individuals were enrolled. Their median age was 71 years an  ...[more]

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