Ontology highlight
ABSTRACT:
SUBMITTER: Shakhmantsir I
PROVIDER: S-EPMC7428848 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Shakhmantsir Iryna I Dooley Scott J SJ Kishore Siddharth S Chen Dechun D Pierce Eric E Bennett Jean J Sehgal Amita A
Journal of biological rhythms 20191115 1
Circadian clocks regulate multiple physiological processes in the eye, but their requirement for retinal health remains unclear. We previously showed that Drosophila homologs of spliceosome proteins implicated in human retinitis pigmentosa (RP), the most common genetically inherited cause of blindness, have a role in the brain circadian clock. In this study, we report circadian phenotypes in murine models of RP. We found that mice carrying a homozygous H2309P mutation in <i>Pre-mRNA splicing fac ...[more]