Dataset Information

Combined Effects of Physical Activity and Air Pollution on Cardiovascular Disease: A Population-Based Study.

ABSTRACT: Background Physical activity (PA), particularly outdoor PA, may have dual effects on cardiovascular disease (CVD) risk: health benefits of exercise and potential harmful effects attributable to increased exposure to air pollution. We examined the combined effects of PA and air pollution on CVD. Methods and Results Sampling from a nationwide cohort study of the Korean National Health Insurance Service, we examined 189 771 adults aged ?40 years who underwent health examination between 2009 and 2010. PA was measured with a questionnaire on the weekly frequency and intensity. Ambient levels of particulate matter 10, 2.5 (PM10, PM2.5) were estimated by the residency of participants. We conducted Cox proportional hazard regression analysis to estimate the relationship between CVD risk and combined effects of PA and air pollution. Subjects with moderate to vigorous PA ?5 times/week and high PM10 exposure had lower risk of CVD (adjusted hazard ratio [aHR], 0.73; 95% CI, 0.62-0.87), coronary heart disease (aHR, 0.76; 95% CI, 0.59-0.98), and stroke (aHR, 0.70; 95% CI, 0.56-0.88). The inverse association between PA and CVD risk was consistent when the analysis was performed for subjects with low/moderate PM10 exposure. When using PM2.5 data, the results were also consistent. Conclusions Moderate to vigorous PA appeared to reduce the risk of CVD within groups of both high and low PM10 or PM2.5 levels. Further studies are needed to validate whether the health benefits of PA outweigh the potential harmful effects resulting from increased exposure to air pollution during PA.

SUBMITTER: Kim SR

PROVIDER: S-EPMC7429004 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Combined Effects of Physical Activity and Air Pollution on Cardiovascular Disease: A Population-Based Study.

Kim Seong Rae SR Choi Seulggie S Keum NaNa N Park Sang Min SM

Journal of the American Heart Association 20200523 11

Background Physical activity (PA), particularly outdoor PA, may have dual effects on cardiovascular disease (CVD) risk: health benefits of exercise and potential harmful effects attributable to increased exposure to air pollution. We examined the combined effects of PA and air pollution on CVD. Methods and Results Sampling from a nationwide cohort study of the Korean National Health Insurance Service, we examined 189 771 adults aged ≥40 years who underwent health examination between 2009 and 201 ...[more]

PMID: 32448042

Similar Datasets

Project description:Psychosocial and environmental stress exposures across the life course have been shown to be relevant in the development of cardiovascular disease (CVD). Assessing more than one stressor from different domains (e.g., individual and neighborhood) and across the life course moves us towards a more integrated picture of how stress affects health and well-being. Furthermore, these individual and neighborhood psychosocial stressors act on biologic pathways, including immune function and inflammatory response, which are also impacted by ubiquitous environmental exposures such as air pollution. The objective of this study is to evaluate the interaction between psychosocial stressors, at both the individual and neighborhood level, and air pollution on CVD. This study used data from the 2009-2011 Behavioral Risk Factor Surveillance System (BRFSS) from Washington State. Adverse childhood experiences (ACEs) measured at the individual level, and neighborhood deprivation index (NDI) measured at the zip code level, were the psychosocial stressors of interest. Exposures to three air pollutants-particulate matter (both PM2.5 and PM10) and nitrogen dioxide (NO?)-were also calculated at the zip code level. Outcome measures included several self-reported CVD-related health conditions. Both multiplicative and additive interaction quantified using the relative excess risk due to interaction (RERI), were evaluated. This study included 32,151 participants in 502 unique zip codes. Multiplicative and positive additive interactions were observed between ACEs and PM10 for diabetes, in models adjusted for NDI. The prevalence of diabetes was 1.58 (95% CI: 1.40, 1.79) times higher among those with both high ACEs and high PM10 compared to those with low ACEs and low PM10 (p-value = 0.04 for interaction on the multiplicative scale). Interaction was also observed between neighborhood-level stressors (NDI) and air pollution (NO?) for the stroke and diabetes outcomes on both multiplicative and additive scales. Modest interaction was observed between NDI and air pollution, supporting prior literature on the importance of neighborhood-level stressors in cardiovascular health and reinforcing the importance of NDI on air pollution health effects. ACEs may exert health effects through selection into disadvantaged neighborhoods and more work is needed to understand the accumulation of risk in multiple domains across the life course.

Dataset Information

Combined Effects of Physical Activity and Air Pollution on Cardiovascular Disease: A Population-Based Study.

Publications

Combined Effects of Physical Activity and Air Pollution on Cardiovascular Disease: A Population-Based Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets