Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC7429848 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhao Zhi Z Wu Jianliang J Xu Huzi H Zhou Cheng C Han Bicui B Zhu Han H Hu Zhizhi Z Ma Zhimei Z Ming Zhangyin Z Yao Ying Y Zeng Rui R Xu Gang G
Cell death & disease 20200814 8
Regulated necrosis has been reported to exert an important role in the pathogenesis of various diseases, including renal ischemia-reperfusion (I/R) injury. Damage to renal tubular epithelial cells and subsequent cell death initiate the progression of acute kidney injury (AKI) and subsequent chronic kidney disease (CKD). We found that ferroptosis appeared in tubular epithelial cells (TECs) of various human kidney diseases and the upregulation of tubular proferroptotic gene ACSL4 was correlated wi ...[more]