Ontology highlight
ABSTRACT:
SUBMITTER: Masson C
PROVIDER: S-EPMC7429854 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Masson Christel C García-García Diana D Bitard Juliette J Grellier Élodie-Kim ÉK Roger Jérôme E JE Perron Muriel M
Cell death & disease 20200814 8
Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected temporal dynamic of gene compensation. At postnatal stages, Taz upregulation occurs, leading to a gain of function-like phenotype characterised by EGFR signalling potentiation and delayed cell-cycle exit of ...[more]