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Online informatics resources to facilitate cancer target and chemical probe discovery

ABSTRACT: This review highlights the cutting-edge informatics resources available to explore cancer genomics, biological, and chemical space to facilitate target and therapeutic discovery in cancer. The advances in cancer genomics, chemical biology, high-throughput screening technologies, and synthetic medicinal chemistry have tremendously expanded the biological space of cancer targets and chemical space of bioactive small molecules to interrogate oncogenic signaling. To explore and leverage these exponentially growing cancer-associated data, a great number of computational tools, databases, and algorithms have been developed. This review summarizes recent cancer-related web resources that allow researchers working at the interface of chemical, biological, and cancer genomics fields to integrate clinical and genomics data for specific actionable targets and selective chemical compounds to facilitate cancer therapeutic discovery.

SUBMITTER: Yang X

PROVIDER: S-EPMC7429978 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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