Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils.
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ABSTRACT:
SUBMITTER: Musteikyte G
PROVIDER: S-EPMC7430317 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils.
Musteikyte Greta G Ziaunys Mantas M Smirnovas Vytautas V
PeerJ 20200814
Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic pr ...[more]
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