Unknown

Dataset Information

0

Functional SARS-CoV-2-specific immune memory persists after mild COVID-19.


ABSTRACT: The recently emerged SARS-CoV-2 virus is currently causing a global pandemic and cases continue to rise. The majority of infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that might contribute to herd immunity. Thus, we performed a longitudinal assessment of individuals recovered from mildly symptomatic COVID-19 to determine if they develop and sustain immunological memory against the virus. We found that recovered individuals developed SARS-CoV-2-specific IgG antibody and neutralizing plasma, as well as virus-specific memory B and T cells that not only persisted, but in some cases increased numerically over three months following symptom onset. Furthermore, the SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral immunity: memory T cells secreted IFN-? and expanded upon antigen re-encounter, while memory B cells expressed receptors capable of neutralizing virus when expressed as antibodies. These findings demonstrate that mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks associated with antiviral protective immunity.

SUBMITTER: Rodda LB 

PROVIDER: S-EPMC7430600 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


The recently emerged SARS-CoV-2 virus is currently causing a global pandemic and cases continue to rise. The majority of infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that might contribute to herd immunity. Thus, we performed a longitudinal assessment of individuals recovered from mildly symptomatic COVID-19 to determine if they develop and sustain immunological memory against the virus.  ...[more]

Similar Datasets

| S-EPMC7682481 | biostudies-literature
| S-SCDT-EMM-2022-15904 | biostudies-other
| S-EPMC7896046 | biostudies-literature
| S-EPMC7991090 | biostudies-literature
| S-EPMC8653411 | biostudies-literature
| S-EPMC8261819 | biostudies-literature
| S-EPMC7924292 | biostudies-literature
| S-EPMC8256672 | biostudies-literature
| S-SCDT-10_15252-EMBR_202256055 | biostudies-other