Ontology highlight
ABSTRACT:
SUBMITTER: Ripperger TJ
PROVIDER: S-EPMC7430613 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ripperger Tyler J TJ Uhrlaub Jennifer L JL Watanabe Makiko M Wong Rachel R Castaneda Yvonne Y Pizzato Hannah A HA Thompson Mallory R MR Bradshaw Christine C Weinkauf Craig C CC Bime Christian C Erickson Heidi L HL Knox Kenneth K Bixby Billie B Parthasarathy Sairam S Chaudhary Sachin S Natt Bhupinder B Cristan Elaine E Aini Tammer El TE Rischard Franz F Campion Janet J Chopra Madhav M Insel Michael M Sam Afshin A Knepler James L JL Capaldi Andrew P AP Spier Catherine M CM Dake Michael D MD Edwards Taylor T Kaplan Matthew E ME Scott Serena Jain SJ Hypes Cameron C Mosier Jarrod J Harris David T DT LaFleur Bonnie J BJ Sprissler Ryan R Nikolich-Žugich Janko J Bhattacharya Deepta D
medRxiv : the preprint server for health sciences 20200815
We conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asympto ...[more]