REM sleep stabilizes hypothalamic representation of feeding behavior.
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ABSTRACT:
SUBMITTER: Oesch LT
PROVIDER: S-EPMC7430996 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
REM sleep stabilizes hypothalamic representation of feeding behavior.
Oesch Lukas T LT Gazea Mary M Gent Thomas C TC Bandarabadi Mojtaba M Gutierrez Herrera Carolina C Adamantidis Antoine R AR
Proceedings of the National Academy of Sciences of the United States of America 20200730 32
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LH<sup>vgat</sup>) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LH<sup ...[more]
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