Elevated energy requirement of cone photoreceptors.

ABSTRACT: We have used recent measurements of mammalian cone light responses and voltage-gated currents to calculate cone ATP utilization and compare it to that of rods. The largest expenditure of ATP results from ion transport, particularly from removal of Na⁺ entering outer segment light-dependent channels and inner segment hyperpolarization-activated cyclic nucleotide-gated channels, and from ATP-dependent pumping of Ca²⁺ entering voltage-gated channels at the synaptic terminal. Single cones expend nearly twice as much energy as single rods in darkness, largely because they make more synapses with second-order retinal cells and thus must extrude more Ca²⁺ In daylight, cone ATP utilization per cell remains high because cones never remain saturated and must continue

SUBMITTER: Ingram NT 

PROVIDER: S-EPMC7431031 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature