Ontology highlight
ABSTRACT:
SUBMITTER: Ingram NT
PROVIDER: S-EPMC7431031 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ingram Norianne T NT Fain Gordon L GL Sampath Alapakkam P AP
Proceedings of the National Academy of Sciences of the United States of America 20200727 32
We have used recent measurements of mammalian cone light responses and voltage-gated currents to calculate cone ATP utilization and compare it to that of rods. The largest expenditure of ATP results from ion transport, particularly from removal of Na<sup>+</sup> entering outer segment light-dependent channels and inner segment hyperpolarization-activated cyclic nucleotide-gated channels, and from ATP-dependent pumping of Ca<sup>2+</sup> entering voltage-gated channels at the synaptic terminal. S ...[more]