Ontology highlight
ABSTRACT:
SUBMITTER: Alexander HK
PROVIDER: S-EPMC7431077 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Alexander Helen K HK MacLean R Craig RC
Proceedings of the National Academy of Sciences of the United States of America 20200723 32
A better understanding of how antibiotic exposure impacts the evolution of resistance in bacterial populations is crucial for designing more sustainable treatment strategies. The conventional approach to this question is to measure the range of concentrations over which resistant strain(s) are selectively favored over a sensitive strain. Here, we instead investigate how antibiotic concentration impacts the initial establishment of resistance from single cells, mimicking the clonal expansion of a ...[more]