Ontology highlight
ABSTRACT:
SUBMITTER: Lumby CK
PROVIDER: S-EPMC7431133 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
eLife 20200810
Strains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the within-host relationship between selection and the stochastic effects of genetic drift, estimating an effective population size of infection N<sub>e</sub> for influenza infection. Examining whole-genome sequence data describing a chronic case of influen ...[more]