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CT abnormalities evocative of lung infection are associated with lower 18F-FDG uptake in confirmed COVID-19 patients.

ABSTRACT: PURPOSE:CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas 18F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 18F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on 18F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing. METHODS:Twenty-two consecutive patients referred for routine 18F-FDG-PET/CT examinations during the COVID-19 outbreak (March 25th to May 15th 2020) and for whom CT slices were evocative of a lung infection were included in the study. All patients had undergone a SARS-COV-2 diagnostic test to confirm COVID-19 infection (positivity was based on molecular and/or serological tests) or exclude it (negativity of at least the serological test). RESULTS:Eleven patients were confirmed to be affected by COVID-19 (COVID+), whereas the other eleven patients were not (COVID-) and were predominantly suspected of having bacterial pneumonia. CT abnormalities were not significantly different between COVID+ and COVID- groups, although trends toward larger CT abnormalities (p?=?0.16) and lower rates of consolidation patterns (0.09) were observed in the COVID+ group. The maximal standardized uptake values (SUVmax) of lung areas with CT abnormalities were however significantly lower in the COVID+ than the COVID- group (3.7?±?1.9 vs. 6.9?±?4.1, p?=?0.03), with the highest SUVmax consistently not associated with COVID-19. CONCLUSION:Among CT abnormalities evocative of lung infection, those related to COVID-19 are associated with a more limited 18F-FDG uptake. This observation may help improve our ability to detect COVID-19 patients.

SUBMITTER: Bahloul A

PROVIDER: S-EPMC7431215 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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CT abnormalities evocative of lung infection are associated with lower <sup>18</sup>F-FDG uptake in confirmed COVID-19 patients.

Bahloul Achraf A Boursier Caroline C Jeulin Hélène H Imbert Laëtitia L Mandry Damien D Karcher Gilles G Marie Pierre-Yves PY Verger Antoine A

European journal of nuclear medicine and molecular imaging 20200818 1

<h4>Purpose</h4>CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas <sup>18</sup>F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 <sup>18</sup>F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on <sup>18</sup>F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing.<h4>Methods</h4>Twenty-two co ...[more]

PMID: 32808079

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Dataset Information

CT abnormalities evocative of lung infection are associated with lower 18F-FDG uptake in confirmed COVID-19 patients.

Publications

CT abnormalities evocative of lung infection are associated with lower <sup>18</sup>F-FDG uptake in confirmed COVID-19 patients.

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