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Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis.


ABSTRACT: In spring 2013, a novel avian-origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta-analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman-Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta-analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high-risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7431636 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis.

Wang Qiang Q   Xu Ke K   Xie Weihua W   Yang Liuqing L   Chen Haiyan H   Shi Naiyang N   Bao Changjun C   Huang Haodi H   Zhang Xuefeng X   Liao Yilan Y   Jin Hui H  

Influenza and other respiratory viruses 20200310 5


In spring 2013, a novel avian-origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta-analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman-Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles wer  ...[more]

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