The aged hematopoietic system promotes hippocampal-dependent cognitive decline.
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ABSTRACT:
SUBMITTER: Smith LK
PROVIDER: S-EPMC7431826 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
The aged hematopoietic system promotes hippocampal-dependent cognitive decline.
Smith Lucas K LK Verovskaya Evgenia E Bieri Gregor G Horowitz Alana M AM von Ungern-Sternberg Saskia N I SNI Lin Karin K Seizer Peter P Passegué Emmanuelle E Villeda Saul A SA
Aging cell 20200721 8
The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus. Here, we report that aging of the hematopoietic system directly contributes to the pro-aging effects of old blood on cognition. Using a heterochronic hematopoietic stem cell (HSC) transplantation model (in which the blood of young mice is reconstituted with old HSCs), we find that exposure to an old hematopoietic system inhibits hippocampal neurogenesis, decreases synaptic marker expression, and impairs cogn ...[more]
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