Ontology highlight
ABSTRACT:
SUBMITTER: Moller SH
PROVIDER: S-EPMC7431954 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Møller Sofie H SH Mellergaard Maiken M Madsen Mikkel M Bermejo Amaia V AV Jepsen Stine D SD Hansen Marie H MH Høgh Rikke I RI Aldana Blanca I BI Desler Claus C Rasmussen Lene Juel LJ Sustarsic Elahu G EG Gerhart-Hines Zachary Z Daskalaki Evangelia E Wheelock Craig E CE Hiron Thomas K TK Lin Da D O'Callaghan Christopher A CA Wandall Hans H HH Andresen Lars L Skov Søren S
Frontiers in immunology 20200811
Immune surveillance of cancer cells is facilitated by the Natural Killer Group 2D (NKG2D) receptor expressed by different lymphocyte subsets. It recognizes NKG2D ligands that are rarely expressed on healthy cells, but upregulated by tumorigenesis, presenting a target for immunological clearance. The molecular mechanisms responsible for NKG2D ligand regulation remain complex. Here we report that cancer cell metabolism supports constitutive surface expression of the NKG2D ligand MHC class I chain- ...[more]