Ontology highlight
ABSTRACT:
SUBMITTER: Khosla K
PROVIDER: S-EPMC7432065 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Khosla Kanika K Naus Christian C CC Sin Wun Chey WC
International journal of molecular sciences 20200723 15
The environment that envelops the cancer cells intimately affects the malignancy of human cancers. In the case of glioma, an aggressive adult brain cancer, its high rate of recurrence after total resection is responsible for a poor prognosis. Connexin43 (Cx43) is a gap junction protein with a prominent presence in glioma-associated normal brain cells, specifically in the reactive astrocytes. We previously demonstrated that elimination of Cx43 in these astrocytes reduces glioma invasion in a syng ...[more]