Ontology highlight
ABSTRACT:
SUBMITTER: Meurer M
PROVIDER: S-EPMC7432635 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Meurer Marita M Öhlmann Sophie S Bonilla Marta C MC Valentin-Weigand Peter P Beineke Andreas A Hennig-Pauka Isabel I Schwerk Christian C Schroten Horst H Baums Christoph G CG Köckritz-Blickwede Maren von MV de Buhr Nicole N
International journal of molecular sciences 20200725 15
<i>Streptococcus</i> <i>suis</i> is a zoonotic agent causing meningitis in pigs and humans. Neutrophils, as the first line of defense against <i>S. suis</i> infections, release neutrophil extracellular traps (NETs) to entrap pathogens. In this study, we investigated the role of the secreted nuclease A of <i>S. suis</i> (SsnA) as a NET-evasion factor in vivo and in vitro. Piglets were intranasally infected with <i>S. suis</i> strain 10 or an isogenic <i>ssnA</i> mutant. DNase and NET-formation we ...[more]