Ontology highlight
ABSTRACT:
SUBMITTER: Zaccak M
PROVIDER: S-EPMC7432781 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zaccak Michael M Qasem Zena Z Gevorkyan-Airapetov Lada L Ruthstein Sharon S
International journal of molecular sciences 20200802 15
Copper's essentiality and toxicity mean it requires a sophisticated regulation system for its acquisition, cellular distribution and excretion, which until now has remained elusive. Herein, we applied continuous wave (CW) and pulsed electron paramagnetic resonance (EPR) spectroscopy in solution to resolve the copper trafficking mechanism in humans, by considering the route travelled by Cu(I) from the metallochaperone Atox1 to the metal binding domains of ATP7B. Our study revealed that Cu(I) is m ...[more]