Ontology highlight
ABSTRACT:
SUBMITTER: Mazumdar A
PROVIDER: S-EPMC7432951 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Mazumdar Alekhya A Urdinez Joaquin J Boro Aleksandar A Migliavacca Jessica J Arlt Matthias J E MJE Muff Roman R Fuchs Bruno B Snedeker Jess Gerrit JG Gvozdenovic Ana A
International journal of molecular sciences 20200730 15
Tumor-secreted extracellular vesicles (EVs) have been identified as mediators of cancer-host intercellular communication and shown to support pre-metastatic niche formation by modulating stromal cells at future metastatic sites. While osteosarcoma, the most common primary malignant bone tumor in children and adolescents, has a high propensity for pulmonary metastases, the interaction of osteosarcoma cells with resident lung cells remains poorly understood. Here, we deliver foundational in vitro ...[more]