ABSTRACT: BACKGROUND:Chinese youth have become more sexually active over the years, yet their behaviours of contraceptive use are influenced by socioeconomic and lifestyle factors. This study aimed to investigate the socioeconomic and lifestyle determinants of contraceptive use among Chinese college students, and to investigate quantitatively their reasons for choosing different contraceptive methods. METHODS:The study used the data from a cross-sectional survey, which was conducted in 2015 among 17,517 students from 130 colleges and professional schools in mainland China. Chi-square tests were performed to test the differences in the awareness and uses of contraceptives between male and female students. Multivariable logistic regression models were used to analyse the associations between socioeconomic and lifestyle factors and contraceptive uses. RESULTS:Condoms (95%), oral contraceptives (91%) and emergency contraceptives (71%) were the most commonly known contraceptive methods among the sample of Chinese youth that were surveyed. Among male participants, high monthly expenditure (OR?=?1.37, 95%CI: 1.07-1.75), light alcohol consumption (OR?=?1.47, 95%CI: 1.03-2.11), and high sexual knowledge (OR?=?1.96, 95%CI: 1.57-2.45) were positively associated with contraceptive uses, while tobacco use (OR?=?0.47, 95%CI: 0.23-0.95) showed a negative association with contraceptive uses. Among female students, suburban residency (OR?=?1.38, 95%CI: 1.03-1.83), high level of parental education (OR?=?1.96, 95%CI: 1.19-3.22), moderate alcohol consumption (OR?=?2.66, 95%CI: 1.05-6.77), and high sexual knowledge (OR?=?1.50, 95%CI: 1.18-1.91) were positively associated with contraceptive uses, while tobacco use (OR?=?0.60, 95%CI: 0.36-0.99) showed a negative association. CONCLUSIONS:A series of socioeconomic and lifestyle factors were associated with contraceptive choices among Chinese college students. Targeted sexual education programs are in demand to improve the awareness and the use of contraceptives in this population.