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Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications.

ABSTRACT: An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

SUBMITTER: LeValley PJ

PROVIDER: S-EPMC7433322 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications.

LeValley Paige J PJ Ovadia Elisa M EM Bresette Christopher A CA Sawicki Lisa A LA Maverakis Emanual E Bai Shi S Kloxin April M AM

Chemical communications (Cambridge, England) 20180601 50

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively. ...[more]

PMID: 29863200

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