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Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19?

ABSTRACT: Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment.

SUBMITTER: Avcilar H 

PROVIDER: S-EPMC7434307 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19?

Avcilar Huseyin H   Eken Ahmet A  

Medical hypotheses 20200818

Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment. ...[more]