The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.
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ABSTRACT:
SUBMITTER: Keck J
PROVIDER: S-EPMC7434643 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.
Keck Jonathon J Chambers James P JP Kancharla Aravind A Bashir Dona Haj DH Henley Laura L Schenkel Katherine K Castillo Kevin K Neal Guentzel M M Gupta Rishein R Arulanandam Bernard P BP
Microbes and infection 20200219 8
Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regula ...[more]
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