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The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.

ABSTRACT: Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.

SUBMITTER: Keck J 

PROVIDER: S-EPMC7434643 | biostudies-literature |

REPOSITORIES: biostudies-literature

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