Ontology highlight
ABSTRACT:
SUBMITTER: Soyal SM
PROVIDER: S-EPMC7434743 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Soyal Selma M SM Kwik Markus M Kalev Ognian O Lenz Stefan S Zara Greta G Strasser Peter P Patsch Wolfgang W Weis Serge S
Molecular genetics & genomic medicine 20200530 8
<h4>Background</h4>The APOE-ε4 allele is an established risk factor for Alzheimer's disease (AD). TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 associations with AD that are independent of APOE-ε4 are at variance.<h4>Methods</h4>We investigated associations of AD with haplotypes defined by three TOMM40 and two APOE single nucleotide polymorphisms in 73 and 71 autopsy cases with intermediate and high likelihood of AD (defined by BRAAK stages <V and V-VI), re ...[more]