Dataset Information

Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia.

ABSTRACT: Myoclonus-dystonia (MD) is a syndrome characterized by myoclonus of subcortical origin and dystonia, frequently associated with psychiatric comorbidities. The motor and psychiatric phenotypes of this syndrome likely result from cortico-striato-thamalo-cerebellar-cortical pathway dysfunction. We hypothesized that reactive and proactive inhibitory control may be altered in these patients. Using the Stop Signal Task, we assessed reactive and proactive inhibitory control in MD patients with (n?=?12) and without (n?=?21) deep brain stimulation of the globus pallidus interna and compared their performance to matched healthy controls (n?=?24). Reactive inhibition was considered as the ability to stop an already initiated action and measured using the stop signal reaction time. Proactive inhibition was assessed through the influence of several consecutive GO or STOP trials on decreased response time or inhibitory process facilitation. The proactive inhibition was solely impaired in unoperated MD patients. Patients with deep brain stimulation showed impairment in reactive inhibition, independent of presence of obsessive-compulsive disorders. This impairment in reactive inhibitory control correlated with intrinsic severity of myoclonus (i.e. pre-operative score). The results point to a dissociation in reactive and proactive inhibitory control in MD patients with and without deep brain stimulation of the globus pallidus interna.

SUBMITTER: Atkinson-Clement C

PROVIDER: S-EPMC7434767 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia.

Atkinson-Clement Cyril C Tarrano Clement C Porte Camille-Albane CA Wattiez Nicolas N Delorme Cécile C McGovern Eavan M EM Brochard Vanessa V Thobois Stéphane S Tranchant Christine C Grabli David D Degos Bertrand B Corvol Jean-Christophe JC Pedespan Jean-Michel JM Krystkoviak Pierre P Houeto Jean-Luc JL Degardin Adrian A Defebvre Luc L Valabregue Romain R Rosso Charlotte C Apartis Emmanuelle E Vidailhet Marie M Pouget Pierre P Roze Emmanuel E Worbe Yulia Y

Scientific reports 20200818 1

Myoclonus-dystonia (MD) is a syndrome characterized by myoclonus of subcortical origin and dystonia, frequently associated with psychiatric comorbidities. The motor and psychiatric phenotypes of this syndrome likely result from cortico-striato-thamalo-cerebellar-cortical pathway dysfunction. We hypothesized that reactive and proactive inhibitory control may be altered in these patients. Using the Stop Signal Task, we assessed reactive and proactive inhibitory control in MD patients with (n = 12) ...[more]

PMID: 32811896

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Project description:BackgroundWorking memory updating (WMU), a controlled process to continuously adapt to the changing task demand and environment, is crucial for cognitive executive function. Although previous studies have shown that the elderly were more susceptible to cognitive interference than the youngsters, the picture of age-related deterioration of WMU is incomplete due to lack of study on people at their middle ages. Thus, the present study investigated the impact of age on the WMU among adults by a cross-sectional design to verify whether inefficiency interference control accounts for the aging of WMU.MethodsIn total, 112 healthy adults were recruited for this study; 28 old adults (21 female) ranging from 60 to 78 years of age; 28 middle-age adults (25 female) ranging from 45 to 59 years of age; 28 adults (11 female) ranging from 26 to 44 years of age; and 28 young adults (26 female) ranging from 18 to 25 years of age. Each participant completed a 1-back task. The inverse efficiency score was calculated in various sequences of three trials in a row to quantify the performance of WMU for adults of various ages.ResultsInverse efficiency score of both young groups (young adult and adult) were significantly shorter than the old group in both Repeat-Alternate (RA, including □□○ and ○○□) and Alternate-Alternate (AA, including ○□○ and □○□) sequential patterns and they were additionally better than the middle-age group in AA sequential pattern.ConclusionWith the increase of difficulty in the task, the difference in reactive interference control between young and middle age was gradually revealed, while the difference between young and old remained to apparent. The degradation of WMU aging may begin from middle-age and presents selective impairment in that only reactive interference control, but not proactive interference control, shows pronounced age-related decline. The preliminary results can inform future studies to further explore the whole lifespan trajectories of cognitive functions.

Dataset Information

Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia.

Publications

Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia.

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