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Understanding of metals dysregulation in patients with systolic and diastolic dysfunction in ischemic heart disease.


ABSTRACT: Ischemic heart disease (IHD) is the leading cause of death and chronic disability in the world. IHD affects both the systolic and diastolic function of the heart which progressively leads to heart failure; a structural and functional impairment of filling or ejection of blood from the heart. In this study, the progression of systolic and diastolic dysfunction characterized according to their echocardiographic parameters including left ventricular ejection fraction (EF), grades of diastolic dysfunction and ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e'), were correlated with differential regulation of various metals in patients sera samples (n?=?62) using inductive coupled plasma-mass spectrometry (ICP-MS). Chromium, nickel and selenium were found significant (p??45%. In patients with systolic dysfunction (EF??45%. Selenium level was also decreased significantly (p?

SUBMITTER: Khan N 

PROVIDER: S-EPMC7434915 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Understanding of metals dysregulation in patients with systolic and diastolic dysfunction in ischemic heart disease.

Khan Noman N   Hashmi Satwat S   Siddiqui Amna Jabbar AJ   Farooq Sabiha S   Sami Shahid Ahmed SA   Basir Nageeb N   Bokhari Syeda Saira SS   Sharif Hasanat H   Junejo Sanaullah S   El-Seedi Hesham R HR   Musharraf Syed Ghulam SG  

Scientific reports 20200818 1


Ischemic heart disease (IHD) is the leading cause of death and chronic disability in the world. IHD affects both the systolic and diastolic function of the heart which progressively leads to heart failure; a structural and functional impairment of filling or ejection of blood from the heart. In this study, the progression of systolic and diastolic dysfunction characterized according to their echocardiographic parameters including left ventricular ejection fraction (EF), grades of diastolic dysfu  ...[more]

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