Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-Fernandez J
PROVIDER: S-EPMC7434922 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gutiérrez-Fernández Javier J Kaszuba Karol K Minhas Gurdeep S GS Baradaran Rozbeh R Tambalo Margherita M Gallagher David T DT Sazanov Leonid A LA
Nature communications 20200818 1
Complex I is the first and the largest enzyme of respiratory chains in bacteria and mitochondria. The mechanism which couples spatially separated transfer of electrons to proton translocation in complex I is not known. Here we report five crystal structures of T. thermophilus enzyme in complex with NADH or quinone-like compounds. We also determined cryo-EM structures of major and minor native states of the complex, differing in the position of the peripheral arm. Crystal structures show that bin ...[more]