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Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function.

ABSTRACT: Alpha-Synuclein (?Syn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson's disease. However, the consequences of ?Syn accumulation to neuronal function are not fully understood. Considering the crucial role of actin on synaptic function and the fact that dysregulation of this cytoskeleton component is emerging in neurodegenerative disorders, the impact of ?Syn on actin is a critical point to be addressed. In this review we explore the link between ?Syn and actin and its significance for physiology and pathology. We discuss the relevance of ?Syn-actin interaction for synaptic function and highlight the actin-depolymerizing protein cofilin-1 as a key player on ?Syn-induced actin dysfunction in Parkinson's disease.

SUBMITTER: Oliveira da Silva MI

PROVIDER: S-EPMC7434970 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function.

Oliveira da Silva Marina I MI Liz Márcia A MA

Frontiers in cell and developmental biology 20200812

Alpha-Synuclein (αSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson's disease. However, the consequences of αSyn accumulation to neuronal function are not fully understood. Considering the crucial role of actin on synaptic function and the fact that dysregulation of this cytoskeleton component is emerging in neurodegenerative disorders, the impact of ...[more]

PMID: 32903460

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