Ontology highlight
ABSTRACT:
SUBMITTER: Kreitman RJ
PROVIDER: S-EPMC7435069 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Leukemia & lymphoma 20190509 12
Hairy cell leukemia (HCL) is an indolent B-cell malignancy, with long-term responses to purine analogs, but with decreasing efficacy and increasing toxicity with repeated courses. Leukemic cells express CD22, CD20, CD25, tartrate-resistant acid phosphatase (TRAP), annexin 1A (Anxa1), and BRAF V600E mutation. HCLv, lacking CD25, Anxa1, TRAP, and BRAF V600E, is more aggressive and less purine analog-sensitive. A molecularly defined IGHV4-34+ variant is also resistant whether HCL or HCLv immunophen ...[more]