Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury.
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ABSTRACT:
SUBMITTER: Florijn BW
PROVIDER: S-EPMC7435264 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury.
Florijn Barend W BW Valstar Gideon B GB Duijs Jacques M G J JMGJ Menken Roxana R Cramer Maarten J MJ Teske Arco J AJ Ghossein-Doha Chahinda C Rutten Frans H FH Spaanderman Marc E A MEA den Ruijter Hester M HM Bijkerk Roel R van Zonneveld Anton Jan AJ
Scientific reports 20200818 1
Left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF) are microcirculation defects following diabetes mellitus (DM). Unrecognized HFpEF is more prevalent in women with diabetes compared to men with diabetes and therefore sex-specific diagnostic strategies are needed. Previously, we demonstrated altered plasma miRs in DM patients with microvascular injury [defined by elevated plasma Angiopoietin-2 (Ang-2) levels]. This study hypothesized the pres ...[more]
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