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Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19.

ABSTRACT: Background:Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. Methods:This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. Results:Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; P < 0.001). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. Conclusions:Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care.

SUBMITTER: Tai S

PROVIDER: S-EPMC7436340 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19.

Tai Shi S Tang Jianjun J Yu Bilian B Tang Liang L Wang Yang Y Zhang Huilin H Zhu Weihong W Xiao Kui K Wen Chuan C Tan Chongqin C Jiang Zhongbiao Z Jiang Chuanhao C Zhu Li L Jiang Li L Liu Qiming Q Hu Xinqun X Fang Zhenfei Z Li Xuping X Sun Jiaxing J Zhu Zhaowei Z Yang Hui H Tu Tao T Xiao Yichao Y Chen Mingxian M He Yuhu Y Chai Xiangping X Xu Junmei J Zhou Shenghua S

Cardiovascular therapeutics 20200801

<h4>Background</h4>Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited.<h4>Methods</h4>This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without ...[more]

PMID: 32874203

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Project description:ObjectiveThis study aimed to determine the prevalence of confirmed novel coronavirus disease 2019 (COVID-19) disease or infants under investigation among a cohort of U.S. neonatal intensive care units (NICUs). Secondarily, to evaluate hospital policies regarding maternal COVID-19 screening and related to those infants born to mothers under investigation or confirmed to have COVID-19.Study designSerial cross-sectional surveys of MEDNAX-affiliated NICUs from March 26 to April 3, April 8 to April 19, May 4 to May 22, and July 13 to August 2, 2020. The surveys included questions regarding COVID-19 patient burden and policies regarding infant separation, feeding practices, and universal maternal screening.ResultsAmong 386 MEDNAX-affiliated NICUs, responses were received from 153 (42%), 160 (44%), 165 (45%), 148 (38%) across four rounds representing an active patient census of 3,465, 3,486, 3,452, and 3,442 NICU admitted patients on the day of survey completion. Confirmed COVID-19 disease in NICU admitted infants was rare, with the prevalence rising from 0.03 (1 patient) to 0.44% (15 patients) across the four survey rounds, while the prevalence of patients under investigation increased from 0.8 to 2.6%. Hospitals isolating infants from COVID-19-positive mothers fell from 46 to 20% between the second and fourth surveys, while centers permitting direct maternal breastfeeding increased 17 to 47% over the same period. Centers reporting universal severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) screening for all expectant mothers increased from 52 to 69%.ConclusionAmong a large cohort of NICU infants, the prevalence of infants under investigation or with confirmed neonatal COVID-19 disease was low. Policies regarding universal maternal screening for SARS-CoV-2, infant isolation from positive mothers, and direct maternal breastfeeding for infants born to positive mothers are rapidly evolving. As universal maternal screening for SARS-CoV-2 becomes more common, the impact of these policies requires further investigation.Key points· In this cohort, neonatal COVID-19 is rare.. · Policies regarding isolation and breastfeeding for infants are rapidly evolving.. · Most hospitals are now providing universal screening for expectant mothers for SARS-CoV-2..

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Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19.

Publications

Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19.

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