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Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial.


ABSTRACT:

Background

Patients with type 2 diabetes mellitus (T2DM) are characterized by chronic hyperglycemia as a consequence of decreased insulin sensitivity, which contributes to bone demineralization and could also be related to changes in serum levels of osteocalcin and insulin, particularly when coupled with a deficiency in the daily consumption of vitamins D3 and K2. The objective of this study was to evaluate the effect of vitamin D3 and vitamin K2 supplements alone or in combination on osteocalcin levels and metabolic parameters in patients with T2DM.

Methods

A double-blind, randomized clinical trial was carried out in 40 patients aged between 30 and 70 years old for 3 months. Clinical and laboratory assessment was carried out at the beginning and at the end of the treatment. The patients were divided into three groups: (a) 1000 IU vitamin D3?+?a calcinated magnesium placebo (n?=?16), (b) 100 µg of Vitamin K2?+?a calcinated magnesium placebo (n?=?12), and (c) 1000 IU vitamin D3?+?100 µg vitamin K2 (n?=?12).

Results

After treatment in the total studied population, a significant decrease in glycemia (p?=?0.001), HOMA-IR (Homeostatic model assessment-insulin resistance) (p?=?0.040), percentage of pancreatic beta cells (p?ConclusionIndividual or combined supplementation with vitamins D3 and K2 significantly decreases the glucose levels and  % of functional pancreatic beta cells, while D3 and D3?+?K2 treatments also induced a reduction in the uOC/cOC index. Only in the group with vitamin D3 supplementation, it was observed a reduction in undercarboxylated osteocalcin while vitamin K2 increased the carboxylated osteocalcin levels.Trial registration NCT04041492.

SUBMITTER: Aguayo-Ruiz JI 

PROVIDER: S-EPMC7436967 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial.

Aguayo-Ruiz J I JI   García-Cobián T A TA   Pascoe-González S S   Sánchez-Enríquez S S   Llamas-Covarrubias I M IM   García-Iglesias T T   López-Quintero A A   Llamas-Covarrubias M A MA   Trujillo-Quiroz J J   Rivera-Leon E A EA  

Diabetology & metabolic syndrome 20200818


<h4>Background</h4>Patients with type 2 diabetes mellitus (T2DM) are characterized by chronic hyperglycemia as a consequence of decreased insulin sensitivity, which contributes to bone demineralization and could also be related to changes in serum levels of osteocalcin and insulin, particularly when coupled with a deficiency in the daily consumption of vitamins D3 and K2. The objective of this study was to evaluate the effect of vitamin D3 and vitamin K2 supplements alone or in combination on os  ...[more]

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