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Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.

ABSTRACT: OBJECTIVE:This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group. METHODS:Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012. RESULTS:Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean? (SE) of 1.2 ?(0.2) kg and 1.8? (0.2) kg, respectively (P?=?0.003). In addition, 31% of ILI and 23.9% of DSE participants gained???2% (P?

SUBMITTER: Look AHEAD Research Group 

PROVIDER: S-EPMC7437140 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.

Chao Ariana M AM   Wadden Thomas A TA   Berkowitz Robert I RI   Blackburn George G   Bolin Paula P   Clark Jeanne M JM   Coday Mace M   Curtis Jeffrey M JM   Delahanty Linda M LM   Dutton Gareth R GR   Evans Mary M   Ewing Linda J LJ   Foreyt John P JP   Gay Linda J LJ   Gregg Edward W EW   Hazuda Helen P HP   Hill James O JO   Horton Edward S ES   Houston Denise K DK   Jakicic John M JM   Jeffery Robert W RW   Johnson Karen C KC   Kahn Steven E SE   Knowler William C WC   Kure Anne A   Michalski Katherine L KL   Montez Maria G MG   Neiberg Rebecca H RH   Patricio Jennifer J   Peters Anne A   Pi-Sunyer Xavier X   Pownall Henry H   Reboussin David D   Redmon Bruce B   Rejeski W Jack WJ   Steinburg Helmut H   Walker Martha M   Williamson Donald A DA   Wing Rena R RR   Wyatt Holly H   Yanovski Susan Z SZ   Zhang Ping P  

Obesity (Silver Spring, Md.) 20200501 5

<h4>Objective</h4>This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.<h4>Methods</h4>Look AHEAD was a randomized controlled trial  ...[more]

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