Ontology highlight
ABSTRACT:
SUBMITTER: Yan W
PROVIDER: S-EPMC7437355 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Yan Wupeng W Markegard Evan E Dharmaiah Srisathiyanarayanan S Urisman Anatoly A Drew Matthew M Esposito Dominic D Scheffzek Klaus K Nissley Dwight V DV McCormick Frank F Simanshu Dhirendra K DK
Cell reports 20200701 3
Sprouty-related, EVH1 domain-containing (SPRED) proteins negatively regulate RAS/mitogen-activated protein kinase (MAPK) signaling following growth factor stimulation. This inhibition of RAS is thought to occur primarily through SPRED1 binding and recruitment of neurofibromin, a RasGAP, to the plasma membrane. Here, we report the structure of neurofibromin (GTPase-activating protein [GAP]-related domain) complexed with SPRED1 (EVH1 domain) and KRAS. The structure provides insight into how the me ...[more]