Ontology highlight
ABSTRACT:
SUBMITTER: Linnemannstons K
PROVIDER: S-EPMC7438013 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Linnemannstöns Karen K Witte Leonie L Karuna M Pradhipa P Kittel Jeanette Clarissa JC Danieli Adi A Müller Denise D Nitsch Lena L Honemann-Capito Mona M Grawe Ferdinand F Wodarz Andreas A Gross Julia Christina JC
Development (Cambridge, England) 20200814 15
Morphogens are important signalling molecules for tissue development and their secretion requires tight regulation. In the wing imaginal disc of flies, the morphogen Wnt/Wingless is apically presented by the secreting cell and re-internalized before final long-range secretion. Why Wnt molecules undergo these trafficking steps and the nature of the regulatory control within the endosomal compartment remain unclear. Here, we have investigated how Wnts are sorted at the level of endosomes by the ve ...[more]