Ontology highlight
ABSTRACT:
SUBMITTER: Huber ST
PROVIDER: S-EPMC7438092 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Huber Stefan T ST Mostafavi Siavash S Mortensen Simon A SA Sachse Carsten C
Science advances 20200819 34
ESCRT-III proteins mediate a range of cellular membrane remodeling activities such as multivesicular body biogenesis, cytokinesis, and viral release. Critical to these processes is the assembly of ESCRT-III subunits into polymeric structures. In this study, we determined the cryo-EM structure of a helical assembly of <i>Saccharomyces cerevisiae</i> Vps24 at 3.2-Å resolution and found that Vps24 adopts an elongated open conformation. Vps24 forms a domain-swapped dimer extended into protofilaments ...[more]