A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome.
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ABSTRACT:
SUBMITTER: Mahadevan J
PROVIDER: S-EPMC7438202 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome.
Mahadevan Jana J Morikawa Shuntaro S Yagi Takuya T Abreu Damien D Lu Simin S Kanekura Kohsuke K Brown Cris M CM Urano Fumihiko F
Laboratory investigation; a journal of technical methods and pathology 20200504 9
Endoplasmic reticulum (ER) stress-mediated cell death is an emerging target for human chronic disorders, including neurodegeneration and diabetes. However, there is currently no treatment for preventing ER stress-mediated cell death. Here, we show that mesencephalic astrocyte-derived neurotrophic factor (MANF), a neurotrophic factor secreted from ER stressed cells, prevents ER stress-mediated β cell death and enhances β cell proliferation in cell and mouse models of Wolfram syndrome, a prototype ...[more]
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