Optimizing bacteriophage engineering through an accelerated evolution platform.

ABSTRACT: The emergence of antibiotic resistance has raised serious concerns within scientific and medical communities, and has underlined the importance of developing new antimicrobial agents to combat such infections. Bacteriophages, naturally occurring bacterial viruses, have long been characterized as promising antibiotic alternatives. Although bacteriophages hold great promise as medical tools, clinical applications have been limited by certain characteristics of phage biology, with structural fragility under the high temperatures and acidic environments of therapeutic applications significantly limiting therapeutic effectiveness. This study presents and evaluates the efficacy of a new accelerated evolution platform, chemically accelerated viral evolution (CAVE), which provides an effective and

SUBMITTER: Favor AH 

PROVIDER: S-EPMC7438504 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature